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We are grateful to Professor Arthur Cho, University of California, Los Angeles, for useful comments after reading this manuscript, helpful discussions, and for the kind gift of DEP samples

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451 In postmortem brain specimens, there were no transcription differences between MDD men and controls, and the levels of 5-HT 1D receptors and the transcription factors NUDR and REST, which regulate 5-HT activity, in 5-HT-containing neurons in the ventral raphe nuclei were found to be higher in MDD females